The scientific focus adapted
to express the optimum potential
of your molecule

Marketing:
Unparalleled vision in metabolic disorders and risk assessment expertise for post-marketing studies and drug repositioning.

HeartArteryMacrophageLiverMusclePancreasAdipose Tissue

Preclinical development:
In-house predictive models and tracer technologies enable the generation of Proof of Concept efficacy data for your drugs.

Discovery:
Screening and lead validation utilize a dedicated research platform which combine with our focused scientific vision.

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Research Services

Overview

Physiogenex is dedicated to support in vivo pharmacology research in the cardiometabolic disease area.

We offer a broad range of predictive diet-induced in vivo models and a unique pharmacology platform integrating a gold-standard collection of services and innovative ex vivo and in vivo screening technologies

Physiogenex provides its clients with an integrated approach to drug discovery, in addition to high-quality and value-added services, with an extensive disease area expertise.

We propose two types of collaboration, on a fee-for-service basis:

  • Preclinical research services: Physiogenex scientific experts collaborate with our clients to prepare a tailor-made experimental program according to their specific needs, which is based on Physiogenex’s validated models and technologies
  • Collaborative discovery programs: Customized experimental programs can be developed in partnership with our clients to develop totally innovative approaches utilizing the unique expertise of Physiogenex (new animal model, screening tools, etc.)

Preclinical services and therapeutic focus

First level phenotyping and screening:

  • In vivo animal models
    • Genetic animal models
    • Diet-induced animal models
  • In vivo functional tests
    • Lipid tolerance test
    • Glucose tolerance test
    • Insulin tolerance test
    • Hepatic lipogenesis
    • Triglycerides/cholesterol absorption
  • Ex vivo assays
    • Glucose uptake
    • Free fatty acid oxidation
    • Lipolysis
      The scientific vision and experience of Physiogenex is a key benefit to all our clients who utilize our services, guiding further drug development

Predictive proof of efficacy services

Physiogenex offers classical or diet-induced predictive pharmacological in vivo models and technical platforms to assess the mechanism of action of your compounds and gain a better understanding of the efficacy / risk ratio.

Our unique platform provides radiotracer-based kinetic methods that enable us to directly assess the efficacy of your compounds, even after acute administration.

“A reduction of hepatic glucose production after acute administration of your compound can be directly demonstrated by the use of our techniques.”

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PathologiesIn vivo pharmacological modelGold standard methods / Key techniques
Lipid Diseases Dyslipidemia Dyslipidemic CETP models
Mixed dyslipidemia / diabetes models
Atherosclerosis
Diabetes / Obesity Diabetes,
Insulin resistance
High fat diet induced models

Genetic animal models
(Db/Db, Ob/Ob, ZDF, .)

Obesity High fat – high sucrose induced models

Genetic models (Zucker, Ob/Ob, .)

  • Indirect calorimetry
  • MRI
  • Adipose tissue function
  • In vivo free fatty acids storage rate
Liver Diseases NAFLD / NASH High fat diet induced models

HFMF cholic acid induced models

Diet-induced NASH / liver fibrosis mouse model

NASH / Fibrosis diet-induced CCl4 models

  • Anatomopathological studies
  • Gene expression profiles (RT qPCR)
  • Cytokines assays
  • Liver injury follow-up
  • HCC cell lines screening
Nutraceuticals Prebiotics and Probiotics; uique validated models to study the impact on metabolic parameters and low grade inflammation

Other high fat diet induced models

  • Intestinal microflora characterization (in partnership with Vaiomer)

Our offer

  • Sreening
  • Phenotyping
  • Kinetic and mechanistic studies with gold standard methods and innovative proprietary technics
  • Customized research models or technics
  • Species: mouse, rat, hamster
  • Non invasive preclinical imaging services

 

Our pharmacology platform delivers:

  • Sensitive methods: 10 % (compared to 25-30% variation with classic technologies)
  • Rapid results
  • Tissue-specific and functional results

We can perform the following:

  • Acute, sub-chronic or chronic efficacy pharmacology studies
  • Drug activity and mechanisms of action in specific animal models
  • Evaluation of adverse effects and/or additional benefits, tissue by tissue
  • Studies of drug combinations