IMMUNOMETABOLISM PRECLINICAL CRO SERVICES

Physiogenex offers immunometabolism preclinical CRO services to evaluate the effects of your drugs on the key role of the immune system on low-grade inflammation in various tissues, leading to metabolic diseases.

Combined with our in vivo experiments, and using Fluorescence-Activated Cell Sorting (FACS) analyses, we validate the efficacy of your treatment:

  • Through the characterization of a current panel of innate and adaptive immune cells in metabolic tissues (e.g. adipose tissue, liver, intestine…),
  • Simultaneously on both the immune system and metabolic parameters,
  • On different tailor-made in vivo models (high fat fed-induced insulin resistance, obesity, NASH in mice, suitable to all mouse models).

Immunometabolism experimental in vivo models

Liver inflammation, innate and adaptative immune system in the 3-week ultrafast NASH mouse screening model :

Immune cell characterization in HFD mice :

Immunometabolism preclinical services

Biochemical assays and histology analysis :

In vivo efficacy studies – screening and profiling :

CONTACT US FOR MORE INFORMATION