IN VIVO METABOLIC STUDIES FOR DRUG EFFICACY

In vivo metabolic studies are a mandatory step for the development of drugs targeting metabolic disorders. Using our unique and benchmarked animal models, we deliver golden-standard and innovative experiments to demonstrate your drugs’ efficacy. Benefit from our validated radio-tracer based experiments and technical platform to dissect the mechanism by which your drug treats metabolic disorders.

In vivo studies proposed by Physiogenex

  • Glucose homeostasis

Glucose tolerance test – GTT
Insulin tolerance test – ITT
Euglycemic hyperinsulinemic clamp
Hyperglycemic clamp
Whole body glucose turnover
In vivo individual tissue glucose uptake

  • Lipid metabolism

Lipid tolerance test
Whole body FFA turnover
In vivo individual tissue FFA storage rate

  • Heart metabolism

In vivo lipid cardiac metabolism
In vivo glucose cardiac metabolism

  • In vivo lipogenesis
  • Molecular imaging

Radioactive tagging of molecules of interest
Biodistribution of original molecules
Evaluation of new therapeutic molecules’ efficacy with validated radiotracers
Phenotypic studies and functional studies on small animal models

  • Preclinical nuclear imaging services

Benefit from our unique imaging services: innovative translational tracers associated with gamma imager, nanoSPECT/CT, nanoPET/CT, ultrasound imaging services.

  • Body composition

Dual Energy X-Ray Absorptiometry (DEXA)

CONTACT US FOR MORE INFORMATION

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