BIOCHEMICAL ASSAYS AND HISTOLOGY ANALYSIS
Biochemical assays and histological analysis are complementary with in vivo / ex vivo studies to fully characterize the potential of your drug candidates and their impact on metabolic molecules and tissues in the organisms.
Physiogenex provides a large range of biochemical assays and histology analyses to evaluate your drug efficacy.
To measure the main readouts needed to demonstrate the benefits of your drugs, we offer:
- Colorimetric assays:
Plasma and hepatic lipids (cholesterol, triglycerides, fatty acids)
Lipoproteins (direct LDL-C and HDL-C assays, lipoprotein FPLC profile, apo A-I, apoB)
Total ketone bodies
Faecal total cholesterol and bile acids
- ELISA and multiplex assays:
Hormones (insulin, glucagon, adiponectin, leptin, etc.)
Cytokines panel (IL-1b, IL-6, MCP-1, TNF-alpha, etc.)
- Western Blot analysis (WES technology): for any protein, on any sample/tissue.
- Microbiome, lipids, bile acids profiling
- Gene expression by qPCR on any tissue:
ER and oxidative stress
- Histology analysis:
Immunohistochemistry (F4/80, CD68, ED1, collagen III, alpha-SMA, etc.)
NAS scoring (steatosis, inflammation, hepatocyte ballooning, fibrosis)
Nephropathy histopathology scoring (glomerulosclerosis, interstitial fibrosis, etc.)
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