Physiogenex offers diabetic nephropathy preclinical CRO services to evaluate your drugs targeting this pathology. We use our unique and benchmarked animal models: the db/db mouse on high protein diet and the Unx/salt supplemented SDT fatty rat models.

Both models were awarded at the 16th World Congress of Insulin Resistance, Diabetes and Cardiovascular Disease in 2018 (see the poster).

Benefit from our experience in measuring the glomerular filtration rate with Medibeacon devices, which enable multiple, sensitive and less invasive measurement of kidney function during drug treatment.

Besides tracking plasma and urine parameters, our clients benefit from our complete histology services panel and histopathology scoring to fully characterize kidney lesions.

Our experience in animal models of diabetic nephropathy and our expertise as consultancy services will optimize and accelerate your drug development program for diabetic nephropathy.

Diabetic nephropathy in vivo models

Nutritional animal models of diabetic nephropathy

Db/db mouse fed a high-protein diet: a fast 4-week mouse model of diabetic nephropathy and glomerular hyperfiltration:

Genetic models of diabetic nephropathy

0.3% salt supplemented/uni-nephrectomized SDT fatty rat – a 10-week rat model of diabetic nephropathy and GFR decline:
The SDT fatty rat, a 10-week cardio-renal model of diabetic nephropathy associated with cardiovascular dysfunction:

Diabetic nephropathy preclinical CRO services

In vivo services

Kidney function: Glomerular Filtration Rate (FITC-sinistrin) using Medibeacon devices

Biochemistry assays and histology

Plasma/urine parameters:

  • Albumin
  • Creatinine
  • Proteinuria

Histology analysis:

  • H&E, PAS, Sirius Red, immunostaining (ED1 for inflammation, col III for fibrosis)
  • Blinded histopathological score
  • Gene and protein expression analysis