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Unparalleled vision in metabolic disorders and risk assessment expertise for post-marketing studies and drug repositioning.

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Preclinical development:
In-house predictive models and tracer technologies enable the generation of Proof of Concept efficacy data for your drugs.

Discovery:
Screening and lead validation utilize a dedicated research platform which combine with our focused scientific vision.

Home > Diabetic Nephropathy

Diabetic Nephropathy

KEY BENEFITS

  • Outstanding scientific expertise and consultancy
  • Innovative in-house diet-induced animal models
  • Gold-standard methods to evaluate kidney fonction and pathology: Glomerular Filtration Rate measurement using FITC-inulin and FITC-sinistrin i.v. injection, albumin/creatinine ratio, histopathology (glomerulosclerosis, inflammation, fibrosis)
  • Dedicated research platform to evaluate the proof of efficacy of your compounds in Diabetic Nephropathy
  • Customized research solutions to target your needs

Animal Experimental Models for Diabetic Nephropathy

0.3% salt supplemented / uni-nephrectomized SDT fatty rat

In-house model: the SDT fatty rat model, developed in partnership with CLEA Japan Inc., is totally devoted to diabetic nephropathy.

Although developed recently, this novel rat model has been already presented in many first-in class international meeting on nephrology – see the last model update presented at the Kidney week 2017

Mouse models of diabetic nephropathy

Physiogenex can also provide mouse models for diabetic nephropahty to evaluate drug efficacy on kidney function and pathological features.

For more information about our mouse models, please contact us