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A Specific Collagen Hydrolysate Improves Postprandial Glucose Tolerance in Normoglycemic and Prediabetic Mice and in a First Proof of Concept Study in Healthy, Normoglycemic and Prediabetic Humans01/09/2025Estelle Grasset, François Briand, Nicolina Virgilio, Christiane Schön, Manfred Wilhelm, Benoit Cudennec, Rozenn Ravallec, Hairati Aboubacar, Sara Vleminckx, Janne Prawitt, Thierry Sulpice, Elien Gevaert, Food Science & Nutrition, 2024; 12:9607–9620https://doi.org/10.1002/fsn3.4538
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A 3-week nonalcoholic steatohepatitis mouse model shows elafibranor benefits on hepatic inflammation and cell death11/12/2024Briand F, Heymes C, Bonada L, Angles T, Charpentier J, Branchereau M, Brousseau E, Quinsat M, Fazilleau N, Burcelin R, Sulpice T.ClinTransl Sci. 2020 May;13(3):529-538. doi: 10.1111/cts.12735. Epub 2020 Jan 25.PMID: 31981449
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Liraglutide shows superior cardiometabolic benefits than lorcaserin in a novel free choice diet-induced obese rat model11/12/2024Briand F, Brousseau E, Maupoint J, Dubroca C, Costard C, Breyner N, Burcelin R, Sulpice T.Eur J Pharmacol. 2020 Sep 5;882:173316. doi: 10.1016/j.ejphar.2020.173316. Epub 2020 Jul 1.PMID: 32621913
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Ezetimibe Enhances Macrophage-to-Feces Reverse Cholesterol Transport in Golden Syrian Hamsters Fed a High-Cholesterol Diet11/12/2024Kasbi Chadli F, Treguier M, Briand F, Sulpice T, Ouguerram K.J Pharmacol Exp Ther. 2020 Oct 23;375(2):349-356. doi: 10.1124/jpet.120.000062.PMID: 32873624
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Elafibranor improves diet-induced nonalcoholic steatohepatitis associated with heart failure with preserved ejection fraction in Golden Syrian hamsters11/12/2024Briand F, Maupoint J, Brousseau E, Breyner N, Bouchet M, Costard C, Leste-Lasserre T, Petitjean M, Chen L, Chabrat A, Richard V, Burcelin R, Dubroca C, Sulpice T.Metabolism. 2021 Apr;117:154707. doi: 10.1016/j.metabol.2021.154707. Epub 2021 Jan 11.PMID: 33444606 Free article.
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Liraglutide targets the gut microbiota and the intestinal immune system to regulate insulin secretion11/12/2024Charpentier J, Briand F, Lelouvier B, Servant F, Azalbert V, Puel A, Christensen JE, Waget A, Branchereau M, Garret C, Lluch J, Heymes C, Brousseau E, Burcelin R, Guzylack L, Sulpice T, Grasset E.ActaDiabetol. 2021 Jul;58(7):881-897. doi: 10.1007/s00592-020-01657-8. Epub 2021 Mar 15.PMID: 33723651
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CX3CR1 regulates gut microbiota and metabolism. A risk factor of type 2 diabetes11/12/2024Pomié C, Servant F, Garidou L, Azalbert V, Waget A, Klopp P, Garret C, Charpentier J, Briand F, Sulpice T, Lelouvier B, Douin-Echinard V, BurcelinR.ActaDiabetol. 2021 Aug;58(8):1035-1049. doi: 10.1007/s00592-021-01682-1. Epub 2021 Mar 22.PMID: 33754166
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The hepatic compensatory response to elevated systemic sulfide promotes diabetes11/12/2024Carter RN, Gibbins MTG, Barrios-Llerena ME, Wilkie SE, Freddolino PL, Libiad M, Vitvitsky V, Emerson B, Le Bihan T, Brice M, Su H, Denham SG, Homer NZM, Mc Fadden C, Tailleux A, Faresse N, Sulpice T, Briand F, Gillingwater T, Ahn KH, Singha S, McMaster C, Hartley RC, Staels B, Gray GA, Finch AJ, Selman C, Banerjee R, Morton NM.Cell Rep. 2021 Nov 9;37(6):109958. doi: 10.1016/j.celrep.2021.109958.PMID: 34758301 Free PMC article.
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Effects of excessive sodium chloride loading in the spontaneously diabetic torii (SDT) fatty rats, a preclinical model of type 2 diabetes mellitus11/12/2024Teoh SH, Miyajima K, Shinozaki Y, Shinohara M, Ohata K, Briand F, Morimoto R, Nakamura Y, Uno K, Kemuriyama N, Nakae D, Ohta T, Maekawa T.J Toxicol Sci. 2021;46(12):589-599. doi: 10.2131/jts.46.589.PMID: 34853244 Free article.
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Improvement of NASH and liver fibrosis through modulation of the gut-liver axis by a novel intestinal FXR agonist11/12/2024Moon AN, Briand F, Breyner N, Song DK, Madsen MR, Kim H, Choi K, Lee Y, Namkung W.BiomedPharmacother. 2024 Apr;173:116331. doi: 10.1016/j.biopha.2024.116331. Epub 2024 Mar 1.PMID: 38428307 Free article.
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Molecular imaging of liver inflammation using an anti-VCAM-1 nanobody11/12/2024Nachit M, Montemagno C, Clerc R, Ahmadi M, Briand F, Bacot S, Devoogdt N, Serdjebi C, Ghezzi C, Sulpice T, Broisat A, Leclercq IA, Perret P.NatCommun. 2023 Feb 24;14(1):1062. doi: 10.1038/s41467-023-36776-7.PMID: 36828835 Free PMC article.
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Nephropathy in diabetic db/db mice is accelerated by high protein diet and improved by the SGLT2 inhibitor dapagliflozin.09/27/2019Oct 05 2019Nørgaard SA, Briand F, Sand FW, Galsgaard ED, Søndergaard H, Sørensen DB, Sulpice T.
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Anacetrapib and dalcetrapib05/06/2019Eur J Pharmacol. 2014 October;740: 135–143.Briand F, Thieblemont Q, Muzotte E, Burr N, Urbain I, Sulpice T, Johns DG.
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Evaluation of Antiatherogenic Properties of Ezetimibe Using 3H-Labeled Low-Density-Lipoprotein Cholesterol and 99mTc-cAbVCAM1-5 SPECT in ApoE-/- Mice Fed the Paigen Diet 201705/06/2019NCBIBriand F, Burr N, Urbain I, Mayoux E, Sulpice T.
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Evaluation of Antiatherogenic Properties of Ezetimibe Using 3H-Labeled Low-Density-Lipoprotein Cholesterol and 99mTc-cAbVCAM1-5 SPECT in ApoE-/- Mice Fed the Paigen Diet05/06/2019EASD, September 14-18, 2015, Stockholm, Sweden.Briand F, Burr N, Urbain I, Mayoux E, Sulpice T.
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Obeticholic acid raises LDL-cholesterol and reduces HDL-cholesterol in the Diet-Induced NASH (DIN) hamster model.01/05/2018NCBI, Jan 05, 2018.Briand F, Brousseau E, Quinsat M, Burcelin R, Sulpice T.
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Probiotic B420 and prebiotic polydextrose improve efficacy of antidiabetic drugs in mice.09/22/2015Diabetol Metab Syndr. 2015 Sep; 12; 7:75.Stenman L.K, Waget A, Garret C, Briand F, Burcelin R, Sulpice T, Lahtinen S.
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Ezetimibe prevents Atherogenesis ahrough increased catabolism and fecal excretion of LDL-cholesterol and reduced atherosclerotic plaque inflammation in ApoE knock-out mice fed a Paigen diet.06/16/2015ATVB, May 7-9, 2015, California, USA.Briand F, Dumas L.S, Broisat A, Ahmadi M, Bacot S, Devoogdt N, Riou L. M, Ghezzi C, Sulpice T.
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Deletion of Apoptosis Signal-Regulating Kinase 1 (ASK1) Protects Pancreatic Beta-Cells from Stress-Induced Death but Not from Glucose Homeostasis Alterations under Pro-Inflammatory Conditions.12/15/2014PLoS One. 2014; 9(11):e112714.Pepin E, Higa A, Schuster-Klein C, Bernard C, Sulpice T, Guardiola B, Chevet E, Alquier T.
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Anacetrapib and dalcetrapib differentially alters HDL metabolism and macrophage-to-feces reverse cholesterol transport at similar levels of CETP inhibition in hamsters.07/07/2014Eur J Pharmacol. 2014 October;740: 135–143.Briand F, Thieblemont Q, Muzotte E, Burr N, Urbain I, Sulpice T, Johns DG.
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Cathepsin S inhibition lowers blood glucose levels in mice.06/13/2014Diabetologia. 2014 August; 57(8): 1674-1683.Lafarge JC, Pini M, Pelloux V, Orasanu G, Hartmann G, Venteclef N, Sulpice T, Shi GP, Clément K, Guerre-Millo M.
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Raising HDL with CETP inhibitor Torcetrapib improves glucose homeostasis in dyslipidemic and insulin resistant hamsters.03/24/2014DEUEL conference on Lipids, March 4 – 7, 2014, California, USA.Briand F, Prunet-Marcassus B, Thieblemont Q, Costard C, Muzotte E, Sulpice T.
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Raising HDL with CETP inhibitor Torcetrapib improves insulin resistance and modulates in vivo tissue glucose uptake in dyslipidemic and insulin resistant hamsters.01/28/2014Atherosclerosis. 2014 233:359-362.Briand F, Prunet-Marcassus B, Thieblemont Q, Costard C, Muzotte E, Sordello S, Sulpice T.
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Raising HDL with CETP inhibitor Torcetrapib improves insulin resistance and modulates in vivo tissue glucose uptake in dyslipidemic and insulin resistant hamsters.11/25/2013American Heart Association, November 16-20, 2013, Dallas, Texas, USA.Briand F, Thieblemont Q, Muzotte E, Sulpice T.
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Liraglutide improves hepatic steatosis and metabolic dysfunctions in a 3-week dietary mouse model of non-alcoholic steatohepatitis.11/25/2013World Diabetes Congress, December 2-6, 2013. Melbourne, Australia.Duparc T, Briand F, Trenteseaux C, Mérian J, Combes G, Najib S, Sulpice T, Martinez L, .
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Cardiac dysfunction in rats with dietary-induced insulin resistance associated with pharmacologically-induced dyslipidemia.05/02/2013Curr Pharm Des. 2013;19(39):6906-11.Tanguy S, Toufektsian MC, Grauzam S, de Leiris J, Ghezzi C, Boucher F, Sulpice T.
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Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass.02/22/2013PLOS Biology. 2013 Feb;11(2).Girousse A, Tavernier G, Valle C, Moro C, Mejhert N, Dinel AL, Houssier M, Roussel B, Besse-Patin A, Combes M, Mir L, Monbrun L, Bézaire V, Prunet-Marcassus B.
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Upregulating reverse cholesterol transport with cholesteryl ester transfer protein inhibition requires combination with the LDL-lowering drug berberine in dyslipidemic hamsters.11/12/2012Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):13-23.Briand F, Thieblemont Q, Muzotte E, Sulpice T.
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Berberine increases LDL-cholesteryl ester catabolism and stimulates LDL-derived cholesterol fecal excretion in hyperlipidemic hamsters.05/25/2012European Atherosclerosis Society Congress, May 25-28, 2012, Milan, Italy .Briand F, Thieblemont Q, Muzotte E , Sulpice T.
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High-fat and fructose intake induces insulin resistance, dyslipidemia, and liver steatosis and alters in vivo macrophage-to-feces reverse cholesterol transport in hamsters.05/24/2012J Nutr. 2012 Apr;142(4): 704-709.Briand F, Thieblemont Q, Muzotte E, Sulpice T.
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Dietary-induced insulin resistance associated with dyslipidemia induces progressive cardiac dysfunction in rats as evidenced by echocardiocardiography05/24/2012Arch Cardiovasc Dis. 2009 Mar;102(S1):22.Grauzam S, Toufektsian MC, Ormezzano O, Jouan MG, Boucher F, Sulpice T.
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AT1 receptor blockade prevents cardiac dysfunction after myocardial infarction in rats05/24/2012Cardiovasc Drugs Ther. 2005 Aug;19(4):251-9.Berthonneche C, Sulpice T, Tanguy S, O'Connor S, Herbert JM, Janiak P, de Leiris J, Boucher F.
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New insights into the pathological role of TNF-alpha in early cardiac dysfunction and subsequent heart failure after infarction in rats05/24/2012Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H340-50.Berthonneche C, Sulpice T, Boucher F, Gouraud L, de Leiris J, O'Connor SE, Herbert JM, Janiak P.
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Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion05/24/2012J Pharmacol Exp Ther. 2003 Sep;306(3):828-37.Leducq N, Bono F, Sulpice T, Vin V, Janiak P, Fur GL, O'Connor SE, Herbert JM.
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EUK-8 a synthetic catalytic scavenger of reactive oxygen species protects isolated iron-overloaded rat heart from functional and structural damage induced by ischemia/reperfusion05/24/2012Cardiovasc Drugs Ther. 1996 Jul;10(3):331-9.Pucheu S, Boucher F, Sulpice T, Tresallet N, Bonhomme Y, Malfroy B, de Leiris J.
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Limiting lipid peroxidation in the nonischemic zone of infarcted rat hearts by indomethacin improves left ventricular function without affecting myocardial healing and remodeling05/24/2012
Sulpice T, Boucher F, de Leiris J.
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Contribution of leukocyte infiltration to lipoperoxidation occurring in the non-ischemic region of the rat heart submitted to permanent left coronary artery occlusion05/24/2012
Sulpice T, Boucher F, Pucheu S, de Leiris J.
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Effect of the antipsychotic agent amisulpride on glucose lowering and insulin secretion.04/24/2012Diabetes Obes Metab. 2012 Apr;14(4):329-34.Roix JJ, Decrescenzo GA, Cheung PH, Ciallella JR, Sulpice T, Saha S, Halse R.
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Sitagliptin promotes macrophage-to-feces reverse cholesterol transport through reduced intestinal cholesterol absorption in obese insulin resistant CETP-apoB100 transgenic mice.01/24/2012Diabetes Obes Metab. 2012 Jul;14(7):662-5.Briand F, Thieblemont Q, Burcelin R, Sulpice T.
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CETP inhibitor Torcetrapib promotes reverse cholesterol transport in obese insulin-resistant CETP-ApoB100 transgenic mice.12/24/2011Clin Transl Sci. 2011 Dec;4(6): 414-420.Briand F, Thieblemont Q, André A, Ouguerram K, Sulpice T.
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An alternative method to measure in vivo reverse cholesterol transport in hyperlipidemic hamsters.12/10/2011Circulation. 2011; 124: A11835.Briand F, Thieblemont Q, Muzotte E, Sulpice T.
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Anacetrapib promotes reverse cholesterol transport and bulk cholesterol excretion in Syrian golden hamsters.11/24/2011J Lipid Res. 2011 Nov;52(11):1965-73.Castro-Perez J, Briand F, Gagen K, Wang SP, Chen Y, McLaren DG, Shah V, Vreeken RJ, Hankemeier T, Sulpice T, Roddy TP, Hubbard BK, Johns DG.
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Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment.09/28/2011EMBO Mol Med. 2011 Sep;3(9):559-72.Amar J, Chabo C, Waget A, Klopp P, Vachoux C, Bermúdez-Humarán LG, Smirnova N, Bergé M, Sulpice T, Lahtinen S, Ouwehand A, Langella P, Rautonen N, Sansonetti PJ, Burcelin R.
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Physiological and pharmacological mechanisms through which the DPP-4 inhibitor Sitagliptin regulates glycemia in mice.09/24/2011Endocrinology. 2011 Aug 15;2(8):3018-29.Waget A, Cabou C, Masseboeuf M, Cattan P, Armanet M, Karaca M, Castel J, Garret C, Payros G, Maida A, Sulpice T, Holst JJ, Drucker DJ, Magnan C, Burcelin R.
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Diet-induced dyslipidemia impairs reverse cholesterol transport in hamsters.09/24/2011Eur J Clin Invest. 2011 Sep;41(9):921-8.Tréguier M, Briand F, Boubacar A, André A, Magot T, Nguyen P, Krempf M, Sulpice T, Ouguerram K.
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La translocation de bactéries intestinales vers les tissus adipeux initie l’inflammation et le diabète induits par un régime gras chez la souris.03/24/2011Diabetes & Metabolism. 2011 Mar;37(1, S1):A7Chabo C, Amar J, Waget A, Klopp P, Vachoux C, Smirnova N, Bergé M, Sulpice T, Lahtinen S, Ouwehand A, Rautonen N, Sansonetti P, Burcelin R.
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Biliary sterol secretion is required for functional in vivo reverse cholesterol transport in mice.03/24/2011Gastroenterology. 2011 Mar;140(3):1043-51.Nijstad N, Gautier T, Briand F, Rader DJ, Tietge UJ.
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Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes.11/24/2010Biochem Pharmacol. 2010 Nov 1;80(9):1450-7.Li X, Millar JS, Brownell N, Briand F, Rader DJ.
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P2Y13 receptor is critical for reverse cholesterol transport.10/24/2010Hepatology. 2010 Oct;52(4):1477-83.Fabre AC, Malaval C, Ben Addi A, Verdier C, Pons V, Serhan N, Lichtenstein L, Combes G, Huby T, Briand F, Collet X, Nijstad N, Tietge UJ, Robaye B, Perret B, Boeynaems JM, Martinez LO.
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Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model.04/24/2010J Lipid Res. 2010 Apr;51(4):763-70.Briand F, Tréguier M, André A, Grillot D, Issandou M, Ouguerram K, Sulpice T.
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The use of dyslipidemic hamsters to evaluate drug-induced alterations in reverse cholesterol transport.03/24/2010Curr Opin Investig Drugs. 2010 Mar;11(3):289-97.Briand F.
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An adiponectin-like molecule with antidiabetic properties.10/24/2009Endocrinology. 2009 Oct;150(10):4493-501.Sulpice T, Prunet-Marcassus B, Molveaux C, Cani P, Vitte PA, Graber P, Dreano M, Burcelin R.
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Pharmacological inhibition of Stearoyl-CoA Desaturase 1 improves insulin sensitivity in insulin-resistant rat models.09/24/2009Eur J Pharmacol. 2009 Sep 15;618(1-3):28-36Issandou M, Bouillot A, Brusq JM, Forest MC, Grillot D, Guillard R, Martin S, Michiels C, Sulpice T, Daugan A.
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Both the Peroxisome Proliferator-Activated Receptor Agonist, GW0742, and Ezetimibe Promote Reverse Cholesterol Transport in Mice by Reducing Intestinal Reabsorption of HDL-Derived Cholesterol.05/24/2009Clin trans Sci. 2009; 2:127-133.Briand F, Naik SU, Fuki I, Millar JS, Macphee C, Walker M, Billheimer J, Rothblat G, Rader DJ.
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Adipose tissue sensitivity to radiation exposure.01/24/2009Am J Pathol. 2009 Jan;174(1):44-53.Poglio S, Galvani S, Bour S, André M, Prunet-Marcassus B, Pénicaud L, Casteilla L, Cousin B.
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The hyperenergetic-fed obese dog, a model of disturbance of apolipoprotein B-100 metabolism associated with insulin resistance: kinetic study using stable isotopes.07/24/2008Metabolism. 2008 Jul;57(7):966-72.Briand F, Bailhache E, Andre A, Magot T, Krempf M, Nguyen P, Ouguerram K.
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Metabolic endotoxemia initiates obesity and insulin resistance.07/24/2007Diabetes. 2007 Jul;56(7):1761-72.Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmée E, Cousin B, Sulpice T, Chamontin B, Ferrières J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R.
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Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions.05/24/2007Diabetologia. 2007 Jun;50(6):1277-87.Fyfe MC, White JR, Taylor A, Chatfield R, Wargent E, Printz RL, Sulpice T, McCormack JG, Procter MJ, Reynet C, Widdowson PS, Wong-Kai-In P.
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Metabolism of high density lipoprotein apolipoprotein A-I and cholesteryl ester in insulin resistant dog: a stable isotope study.01/24/2007Diabetes Obes Metab. 2007 Jan;9(1):139-42.Briand F, Bailhache E, Nguyen P, Krempf M, Magot T, Ouguerram K.
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Fenofibrate lowers lipid parameters in obese dogs.08/24/2006Nutr. 2006 Jul;136(7 Suppl):2037S-2040S.Serisier S, Briand F, Ouguerram K, Siliart B, Magot T, Nguyen P.
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Atorvastatin increases intestinal cholesterol absorption in dogs.07/24/2006J Nutr. 2006 Jul;136(7 Suppl):2034S-2036S.Briand F, Serisier S, Krempf M, Siliart B, Magot T, Ouguerram K, Nguyen P.
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From heterogeneity to plasticity in adipose tissues: site-specific differences.05/24/2006Exp Cell Res. 2006 Apr 1;312(6):727-36.Prunet-Marcassus B, Cousin B, Caton D, André M, Pénicaud L, Casteilla L.
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Effects of atorvastatin on high-density lipoprotein apolipoprotein A-I metabolism in dogs.04/24/2006Eur J Clin Invest. 2006 Apr;36(4):224-30.Briand F, Magot T, Krempf M, Nguyen P, Ouguerram K.
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Fenofibrate prevents Rosiglitazone-induced body weight gain in ob/ob mice05/24/2005Int J Obes. 2005 Jul;29(7):864-71.Carmona MC, Louche K, Nibbelink M, Prunet B, Bross A, Desbazeille M, Dacquet C, Renard P, Casteilla L, Pénicaud L.
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Selective uptake of high density lipoproteins cholesteryl ester in the dog, a species lacking in cholesteryl ester transfer protein activity: an in vivo approach using stable isotopes.09/24/2004Comp Biochem Physiol B Biochem Mol Biol. 2004 Aug;138(4):339-45.Ouguerram K, Nguyen P, Krempf M, Pouteau E, Briand F, Bailhache E, Magot T.
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Metabolism of cholesterol ester of apolipoprotein B100-containing lipoproteins in dogs: evidence for disregarding cholesterol ester transfer.08/24/2004Eur J Clin Invest. 2004 Aug;34(8):527-34.Bailhache E, Briand F, Nguyen P, Krempf M, Magot T, Ouguerram K.
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Melatonin reduces body weight gain in Sprague Dawley rats with diet-induced obesity05/24/2003Endocrinology. 2003 Dec;144(12):5347-52.Prunet-Marcassus B, Desbazeille M, Bros A, Louche K, Delagrange P, Renard P, Casteilla L, Pénicaud L.
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Evidence for a direct effect of melatonin on mitochondrial genome expression of Siberian hamster brown adipocytes.05/24/2001J Pineal Res. 2001 Mar;30(2):108-15.Prunet-Marcassus B, Ambid L, Viguerie-Bascands N, Pénicaud L, Casteilla L.
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Inverse distribution of uncoupling proteins expression and oxidative capacity in mature adipocytes and stromal-vascular fractions of rat white and brown adipose tissues.05/24/1999FEBS Lett. 1999 Dec 31;464(3):184-8.Prunet-Marcassus B, Moulin K, Carmona MC, Villarroya F, Pénicaud L, Casteilla L.