GLP-1 EXPERTISE
Physiogenex has a >15-year experience in developing GLP-1/incretins therapies: let’s drive you to success
Expertise in GLP-1
Benefits from our consulting services – includes Pr. Rémy Burcelin’s expertise , Physiogenex chairman of the scientific advisory board (50 publications on GLP-1)
Discriminate the mechanism of actions
Benefits from our consulting services:
Pancreatic insulin secretion
Gut-brain axis
Gastric emptying immunomodulation
Our validated tools:
Acute effects: gastric emptying in mice & glucose tolerance tests 
Chronic effects: Weight loss in DIO rats
Beta-cells preservation in ZDF rats
NASH/MASH & liver immune cells modulation in 3-week NASH/MASH mouse
Diabetic nephropathy & cardiovascular in the SDT fatty rat
Preclinical CRO Services for obesity, insulin resistance and diabetes
Ex vivo screening
- Muscles/adipocytes ex vivo glucose uptake
- Muscles/adipocytes ex vivo FFA oxydation
- Adipocytes ex vivo lipolysis
In vivo drug efficacy experiments
Glucose homeostasis
- Glucose and insulin tolerance test
- Hyperinsulinemic euglycemic/hyperglycemic clamps with 3H-glucose (hepatic glucose production, turnover, glycolysis, etc.) and 14C-2-deoxyglucose (glucose uptake)
- In vivo individual tissue glucose uptake
Lipid metabolism
- Lipid tolerance test
- Lipogenesis in vivo with 3H2O or 14C-acetate
In vivo services
- Body weight food/water intake, organs collection, weight and fixation (fat pads, liver, etc.), blood collection and tissue dissection
- Cardiometabolic parameters (echocardiography)
- Indirect calorimetry (energy expenditure), Minispec (body composition)
in vivo studies
Biochemistry assays and histology
- Standard hormones (insulin, glucagon, adiponectin, leptin, etc.)
- Inflammation (plasma cytokines)
- Tissue analysis (lipids, gene and protein expression)
- Histology, immunohistology and histopathological scoring
biochemical assays and histology analysis
Our major scientific publications on obesity, insulin resistance and diabetes:
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