The scientific focus adapted
to express the optimum potential
of your molecule

Marketing:
Unparalleled vision in metabolic disorders and risk assessment expertise for post-marketing studies and drug repositioning.

HeartArteryMacrophageLiverMusclePancreasAdipose Tissue

Preclinical development:
In-house predictive models and tracer technologies enable the generation of Proof of Concept efficacy data for your drugs.

Discovery:
Screening and lead validation utilize a dedicated research platform which combine with our focused scientific vision.

Home > In vivo individual tissue glucose uptake

in vivo individual tissue glucose uptake

Unique solution for assessing the efficacy of your compound designed to treat type 2 diabetes on in vivo glucose uptake, tissue by tissue.

key benefits

  • In-house validated technique
  • Information for stratifying future patient populations, with the effect of your compounds on specific tissues.
  • Insights for devising ex vivo tissue assays for screening your hit compounds.
  • Identifying additional in vivo effects in specific tissues that would not have been seen in any other type of experiment.
  • Anticipating adverse effects on major tissues: brain, heart, muscle and adipose tissue.

description and parameters

The individual tissue technique using radiotracers provides critical information on additional tissue-specific benefits as well as unwanted effects on key tissues, for rapid strategic decision-making.

Species

  • Rat
  • Mouse

Reference compounds

  • Rosiglitazone

Parameters evaluated

  • Muscle glucose uptake: Extensor digitorium longus (EDL), Vastus lateralis (VL), Soleus (SOL),…
  • White adipose tissue (WAT) glucose uptake: subcutaneous, visceral
  • Organ glucose uptake: brain, heart and brown adipose tissues (BAT)

Add-on studies

  • Free faty acid turnover with specific emphasis on individual tissue FFA storage rate, yielding a whole body tissue-by-tissue overview of the effect of your compound on lipotoxicity.

Fact sheet

r259_16_in_vivo_individual_tissue_glucose_uptake_-_physiogenex_thumbnail

REFERENCES

Knauf C. et al, J Clin Invest, 2005, 115: 3554-63.
Cook S. et al, Diabetes, 2004, 53:2067-72.
Burcelin R. et al, Diabetes, 1999, 48: 16264-9.