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Home > In vivo individual tissue free fatty acids storage rate

in vivo individual tissue FFA storage rate

Gold-standard and unique solution for assessing the efficacy of your compound designed to treat type 2 diabetes  and/or obesity on in vivo fatty acids turnover and  incorporation in triglycerides, tissue by tissue

key benefits

  • The individual tissue technique using radiolabelled tracers provides critical information on additional tissue-specific benefits as well as unwanted effects on key tissues for rapid strategic decision-making
  • Information for stratifying future patient populations, with the effect of your compounds on specific tissues
  • Insights for devising ex vivo tissue assays for screening your hit compounds
  • Identifying additional in vivo effects in specific tissues that would not have been seen in any other type of experiment
  • Anticipating adverse effects on major tissues: liver, heart, muscle, and adipose tissues

description and parameters

Whole body free fatty acid turnover with specific emphasis on individual tissue triglycerides incorporation and storage rates.

Species

  • Rat
  • Mouse

Reference compounds

  • Rosiglitazone

Parameters evaluated

  • Muscle fatty acids uptake and incoporation in the TG pool: Extensor digitorium longus (EDL), Vastus lateralis (VL), Soleus (SOL),…
  • White (WAT) and brown (BAT) adipose tissue fatty acids uptake and incorporation in the TG pool : subcutaneous, visceral
  • Organ fatty acids uptake and incorporation in the triglycerides pool : liver, heart, pancreas, …

Fact sheet

in vivo individual tissue FFA storage rate

REFERENCES

Girousse A. et al, PLOS Biology, 2013, 11(2).