The scientific focus adapted
to express the optimum potential
of your molecule

Marketing:
Unparalleled vision in metabolic disorders and risk assessment expertise for post-marketing studies and drug repositioning.

HeartArteryMacrophageLiverMusclePancreasAdipose Tissue

Preclinical development:
In-house predictive models and tracer technologies enable the generation of Proof of Concept efficacy data for your drugs.

Discovery:
Screening and lead validation utilize a dedicated research platform which combine with our focused scientific vision.

Obesity

Overweight and obesity are defined as abnormal or excessive fat accumulation that may impair health. Obesity is associated with a number of chronic conditions such as cardiovascular and cerebrovascular diseases, type 2 diabetes and dyslipidemia and is a major cause of death.

The World Health Organization estimates that 10 % of the world’s adult population was obese in 2008. The global incidence of obesity is continuing to rise worldwide.

KEY BENEFITS

  • Outstanding scientific expertise and consultancy
  • Gold-standard methods and novel in-house techniques
  • Dedicated research platform to evaluate the therapeutic potential of your compounds in obesity and other metabolic disorders and cardiovascular complications
  • Customized research solutions to target your needs

Animal Experimental Models

Nutrional animal models

High fat diet mouse (60% fat)

A reference mouse model dedicated to diabetes and obesity studies. ico-link

High fat diet mouse model 60%

Diet Induced Obesity (DIO) rat (40% fat)

A diet induced obesity rat model that exhibit hyperglycemia, impaired insulin secretion, hepatic and peripheral resistance. A model to study pre-diabete type 2 diabetes and obesity. ico-link

Diet induced Obesity (DIO) rat model

Diet Induced Obesity (DIO) mouse (60% fat)

A diet-induced mouse model exhibiting visceral adiposity, insulin resistance, hyperinsulinemia, hyperleptinemia, and leptin resistance. A model to study pre-diabete type 2 diabetes and obesity. ico-link

Diet-induced obesity (DIO) mouse model

Genetic animal models

Ob/ob mouse

A leptin-deficient mouse model for type 2 diabetes, obesity.

Ob / ob mouse

Db/db mouse

A leptin-deficient mouse model to study diabetes, obesity and diabetic dyslipidemia.

Zucker Diabetic Fatty (ZDF) rat

A genetic rat model for the study of type 2 diabetes, hyperglycemia, insulin resistance, hyperinsulinemia, hypertriglyceridemia, hypercholesterolemia and cardiovascular or renal complications.

Zucker Diabetic Fatty (ZDF) rat

Zucker fatty rat

A genetic rat model of obesity, insulin resistance and hypertension.

Read-Outs

In vivo screening and profiling
Glucose homeostasis
Complementary techniques associated to diabetes and insulin resistance ico-linkYesYes
Lipid metabolism
Lipogenesis in vivoYesYes
Complementary techniques associated to lipid disorders ico-linkYesYes
Non invasive imaging services
Body compositionDual Energy X-Ray Absorptiometry (DEXA)
Biochemistry / Biomarkers, Cardiometabolic parameters and other services
Biochemistry / Biomarkers ico-linkYesYes
Indirect calorimetry YesYes
Cardiometabolic parametersYesYes
Basic servicesBody weight, Fat pad weight, Food intake, Lipid homeostasis, Blood collection and tissue harvesting