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Unparalleled vision in metabolic disorders and risk assessment expertise for post-marketing studies and drug repositioning.

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Home > Research services > Dyslipidemia – Atherosclerosis

Dyslipidemia – Atherosclerosis

Dyslipidemia is an abnormal amount of lipids (e.g. high LDL-cholesterol levels or triglycerides) in the blood. In 2009, dyslipidemia was reported to cause the highest prevalence in cardiovascular disorders in developed countries, often due to western diet and lifestyle.

Dyslipidemia and atherosclerosis are two of the most important risk factors for cardiovascular diseases which are a major cause of morbidity and a leading cause of mortality worldwide.

KEY BENEFITS

  • Outstanding scientific expertise and consultancy
  • Innovative in-house diet-induced animal models
  • Gold-standard methods and innovative techniques (the ox-LDL proprietary technique) to measure  reverse cholesterol transport (RCT)
  • Customized research solutions to target your needs

Animal Experimental Models

Nutrional animal models

ApoE KO and LDL-receptor KO mouse models

In-house models: mouse models of atherosclerosis under high fat diet to demonstrate effects of your drug on atherosclerosis reduction with radio-tracer based methods and VCAM-1 imaging technique to detect inflammation inside atherosclerotic plaques. ico-link

Insulin Resistant and dyslipidemic hamster model

In-house model: A hamster model that under a high fat diet exhibit insulin resistance/diabetes, dyslipidemia and hepatic steatosis. ico-link

Insulin resistant and dyslipidemic hamster model

Hypercholesteromic hamster model

In-house model: A hamster model that under a high fat diet exhibit a lipoprotein metabolism similar to humans (e.g.: high LDL-C levels and higher CETP activity). ico-link

Hypercholesterolemic hamster

High fat diet CETP-apoB100 mouse model

In-house model: A genetically modified mouse model that contains both human apoliprotein B and CETP transgenes. The animal develops atherosclerosis on a high fat and high cholesterol diet. ico-link

CETP ApoB100 mouse high fat diet model

Genetic animal models

ApoE KO mouse or LDL-receptor KO mouse

A constitutive KO model for cardiovascular disease. The mouse develops high level of plasma cholesterol and spontaneous atherosclerotic lesions while fed a standard diet.

ApoB 100 mouse

A genetically modified mouse model that contains the human apoliprotein B transgene. The animal develops atherosclerosis on a high fat diet.

CETP mouse

A genetically modified mouse model that contains the human CETP transgene. The animal presents very low levels of plasma HDL cholesterol.

Ob/ob mouse

A leptin-deficient mouse model for type 2 diabetes, obesity.

Ob / ob mouse

Db/Db

A leptin-deficient mouse model to study diabetes, obesity and diabetic dyslipidemia.

Zucker Diabetic Fatty (ZDF) rat

A genetic rat model for the study of type 2 diabetes, hyperglycemia, insulin resistance, hyperinsulinemia, hypertriglyceridemia, hypercholesterolemia and cardiovascular or renal complications.

Zucker Diabetic Fatty (ZDF) rat

Zucker fatty rat

A genetic rat model of obesity, insulin resistance and hypertension.

Technical Platform / Read-Outs

In vivo screening and profiling
Lipid metabolism
Macrophage-to-feces reverse cholesterol transport ico-linkGold-standard method
ox-LDL reverse cholesterol transport ico-linkIn-house innovative and validated technique
HDL / LDL-cholesterol turnover ico-linkGold-standard method
Intestinal triglycerides/cholesterol absorption ico-linkIn-house validated technique
Whole body FFA turnover ico-linkGold-standard method
In vivo individual tissue FFA storage rate ico-linkGold-standard method
VLDL-TG production test ico-linkIn-house validated technique
Glucose homeostasis
Euglycemic hyperinsulinemic clamp ico-linkGold-standard method
Hyperglycemic clamp ico-linkGold-standard method
Ex vivo screening
Muscles / Adipocytes ex vivo FFA oxydation ico-linkIn-house validated technique
Muscles / Adipocytes ex vivo glucose uptake ico-linkIn-house validated technique
Biochemistry / Biomarkers, Cardiometabolic parameters and other services
Biochemistry / Biomarkers ico-linkYesYes
Lipid tolerance test ico-linkYesYes
Faeces analyses ico-linkYesYes
FPLC lipoprotein profilingYesYes
Histopathology YesYes
Cardiometabolic parametersYesYes
Basic servicesBody weight, Food intake, Lipid homeostasis, Blood collection and tissue harvesting
Non invasive imaging services
Preclinical nuclear imaging services Benefit of unique imaging services with innovative translational tracers associated with gamma imager, nanoSPECT/CT, nanoPET/CT, ultrasound imaging devices