10/30/2017 Physiogenex and CLEA Japan Inc. to present at the Kidney Week 2017, Oct. 31st- Nov. 5th, 2017, New Orleans, LA, USA.
Dapagliflozin Alone or Combined with Ramipril Improves Hyperglycemia and Hypertension and Prevents Kidney Complications and GFR Decline in the Nephrectomized SDT Fatty Rat Model of Diabetic Nephropathy.
Through their partnership put in place in January 2016,
Physiogenex and CLEA Japan Inc. have worked thoroughly to set-up and validate a novel rat model for evaluating drugs targeting Diabetic Nephropathy.
The Spontaneously Diabetic Torii fatty (SDT fatty) rat, a model of obesity type 2 diabetes distributed by CLEA Japan Inc. since 2012, has been optimized to fit with preclinical requirements for developing drugs targeting Diabetic Nephropathy.
Within only 10 weeks, this obese and diabetic rat model develops advanced kidney complications, with a >50% glomerular filtration rate (GFR) decline.
This rat model was used to evaluate the effects of dapagliflozin, a SGLT2 inhibitor, alone or in combination with ramipril, an ACE inhibitor.
The study will be presented by Dr. François Briand, Director of Research and Business Development at Physiogenex, during the Diabetes Mellitus, Obesity: Basic-Experimental – II poster session, on Friday, November 3rd , 2016 10:00 AM – 12:00 PM (poster #FR-PO592)
CLEA representatives, including Dr. Shinohara, the expert who established the SDT fatty rat model, will be also on site to provide information about the model during the conference.
If you wish to know more about the SDT fatty rat model for Diabetic Nephropathy for setting-up a drug evaluation, ask Physiogenex experts:
If you wish to know more about the SDT fatty rat model for obesity/type 2 diabetes, contact CLEA Japan Inc.:
About CLEA Japan, Inc.
CLEA Japan, Inc. is the expert supplier of experimental rodents, constantly providing best quality bioservices to researchers. Based on its experience acknowledged by pharmaceutical companies, CLEA Japan, Inc. will efficiently provide CRO services with Physiogenex.
Find out more about CLEA Japan, Inc. and the services offered at
Physiogenex is a leading preclinical research organization providing non clinical services in metabolic disorders and complications. We offer in vivo translational diseases models as well as ex vivo assays to support efficacy and pharmacological assays. We focus on metabolic diseases, diabetes, insulin resistance, obesity, dyslipidemia, liver diseases (NASH to fibrosis) and renal complications.
Please visit our website for more information: https://www.physiogenex.com