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Home > News > Physiogenex and CLEA Japan Inc. present the benefits of SGLT2 inhibitor dapagliflozin on their 10-week rat model for evaluating drugs targeting Diabetic Nephropathy at the World Congress of Nephrology in Mexico

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04/04/2017 Physiogenex and CLEA Japan Inc. present the benefits of SGLT2 inhibitor dapagliflozin on their 10-week rat model for evaluating drugs targeting Diabetic Nephropathy at the World Congress of Nephrology in Mexico

Through their partnership put in place in January 2016,

Physiogenex and CLEA Japan Inc. have worked thoroughly to set-up and validate a novel rat model for evaluating drugs targeting Diabetic Nephropathy.

The Spontaneously Diabetic Torii fatty (SDT fatty) rat, a model of obesity type 2 diabetes distributed by CLEA Japan Inc. since 2012, has been optimized to fit with preclinical requirements for developing drugs targeting Diabetic Nephropathy.

Within only 10 weeks, this obese and diabetic rat model develops advanced kidney complications, with a >50% glomerular filtration rate (GFR) decline.

The study will be presented by Dr. François Briand, Director of Research and Business Development at Physiogenex during the Sunday moderated poster session at the World Congress of Nephrology on Sunday, April the 23rd, 2016, noon to 1:15pm.

CLEA representatives, including Dr. Shinohara, the expert who established the SDT fatty rat model, will be also on site to provide information about the model during the conference.

View the abstract

If you wish to know more about the SDT fatty rat model for Diabetic Nephropathy for setting-up a drug evaluation, ask Physiogenex experts

If you wish to know more about the SDT fatty rat model for obesity/type 2 diabetes, contact CLEA Japan Inc

About CLEA Japan, Inc.

CLEA Japan, Inc. is the expert supplier of experimental rodents, constantly providing best quality bioservices to researchers. Based on its experience acknowledged by pharmaceutical companies, CLEA Japan, Inc. will efficiently provide CRO services with Physiogenex.

Find out more about CLEA Japan, Inc. and the services offered

About Physiogenex

Physiogenex is a leading preclinical research organization providing non clinical services in metabolic disorders and complications. We offer in vivo translational diseases models as well as ex vivo assays to support efficacy and pharmacological assays. We focus on metabolic diseases, diabetes, insulin resistance, obesity, dyslipidemia, liver diseases (NASH to fibrosis) and renal complications.

Please visit our website for more information