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Home > Muscles/ Adipocyte ex vivo glucose uptake

muscles / adipocytes ex vivo glucose uptake

A simple and rapid technique for assessing your compound’s direct effect on glucose uptake in type 2 diabetes and/or obesity.

This method can be used both for medium throughput screening and for initial ex vivo proof-of-concept.

Key Benefits

  • In-house validated technique
  • Ex vivo validation on glucose uptake in isolated muscles (a major contributor to blood glucose control).
  • Ex vivo validation on glucose uptake in isolated adipocytes for drugs targeting these cells.
  • Insights into obesity and/or insulin resistance.
  • Select your best candidates with an inexpensive, reproducible and rapid technique before launching in vivo validation.

Description and parameters

Species

  • Rat
  • Mouse
  • Hamster

Parameters evaluated

Glucose uptake in isolated mouse muscles after 12 weeks of diet
Glucose uptake in isolated mouse muscles after 12 weeks of diet
Glucose uptake in isolated mouse adipocytes after 12 weeks of diet
Glucose uptake in isolated mouse adipocytes after 12 weeks of diet

Add-on studies

Fact sheet

Muscles adipocytes ex vivo glucose uptake

REFERENCES

Viollet B. et al, J. Clin Invest 2003, 111: 3554-63.
Duplain H. et al, Circulation 2001,104: 342-5.