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Unparalleled vision in metabolic disorders and risk assessment expertise for post-marketing studies and drug repositioning.

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In-house predictive models and tracer technologies enable the generation of Proof of Concept efficacy data for your drugs.

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Home > Methionine Choline Deficient (MCD) diet mouse model

MCD mouse model

A classical NASH mouse model that enables a fast pharmacological study to rapidly evaluate the efficacy of drugs on NASH / NAFLD

key benefits

The Methionine Choline deificient diet fed mouse model’s enables a fast and costless efficacy screening tool of your compounds:

  • a classical NASH mouse model
  • short-time liver injury set-up (4 to 8 weeks)
  • small amounts of compounds
  • quick turn-over time (within ~3 months)

pharmacological validation

  • Positive reference compounds: PPAR gamma agonist pioglitazone, FXR agonists WAY-362450 and obeticholic acid (OCA)