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In-house predictive models and tracer technologies enable the generation of Proof of Concept efficacy data for your drugs.

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Home > Lipid tolerance test

Lipid tolerance test

First in vivo proof of concept of the impact of your compound designed to treat type 2 diabetes on cardiovascular complications and/or dyslipidemia, in terms of whole-body lipid homeostasis.

Key benefits

  • Suitable for large-scale screening in vivo (20-30 compounds/week).
  • Yielding in vivo insights into your compound’s efficacy in treating cardiovascular complications and/or dyslipidemia associated with type 2 diabetes
  • Sensitivity (15%) to detect a statistically significant impact of your compound on postprandial blood lipid regulation


Description and parameters

The Lipid tolerance test investigates how dyslipidemic animals treated with your compound regulate triglycerides and free fatty acids after lipid intake.


  • Rat
  • Mouse

Lipid tolerance test in awake rats after 6 weeks of diet
Lipid tolerance test in awake rats after 6 weeks of diet

Add-on studies