insulin tolerance test
- Capacity to screen compounds in vivo on a large scale (20-30 compounds/week), with a fast and reproducible in vivo technique
- Sensitivity (15%) to detect a statistically significant impact of your compound on insulin sensitivity
Description and parameters
The insulin tolerance test shows how diabetic animals regulate their glycemia after insulin stimulation.
- Plasma glucose
- Euglycemic hyperinsulinemic clamp + 3H glucose to further investigate the effect of your compound on insulin sensitivity in a “gold standard” test for preclinical validation or lead selection.
- Glucose tolerance test and Lipid tolerance test on the same animals to reinforce your validation on complementary issues.