The scientific focus adapted
to express the optimum potential
of your molecule

Marketing:
Unparalleled vision in metabolic disorders and risk assessment expertise for post-marketing studies and drug repositioning.

HeartArteryMacrophageLiverMusclePancreasAdipose Tissue

Preclinical development:
In-house predictive models and tracer technologies enable the generation of Proof of Concept efficacy data for your drugs.

Discovery:
Screening and lead validation utilize a dedicated research platform which combine with our focused scientific vision.

Home > Hyperglycemic clamp

Hyperglycemic clamp

State-of-the-art method for investigating your compound’s efficacy on pancreatic ß-cell function in type 2 diabetes.
Hyperglycemia is maintained to stimulate insulin secretion.

key benefits

  • Sensitivity to detect a statistically significant impact of your compound on insulin secretion,
  • Designed to gain an overview of pancreatic β-cell function in vivo
  • Essential and robust data for your records:  a unique tool simultaneously integrating all factors involved in the control of insulin secretion (metabolites, hormones, neuroregulatory factors)

description and parameters

Species

  • Rat
  • Mouse

Parameters evaluated

Hyperglycemic clamp in awake mice
Hyperglycemic clamp in awake mice

Add-on studies

  • GLP-1 active form in the portal vein after an oral glucose load, to investigate the efficacy of your compound on GLP-1 production.

REFERENCES

Knauf C. et al, J Clin Invest, 2005, 115: 3554-63.
Burcelin R. et al, Diabetes, 2001, 50 : 1282-9.
Thorens B. et al, J. Biol.Chem, 2000, 275: 23751-8.