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Home > Glucose tolerance test

Glucose tolerance test

First in vivo proof of concept of the impact of your compound designed to treat type 2 diabetes on whole-body glucose homeostasis.

Key benefits

  • Large-scale screening (IPGTT 20-30 compounds/week and OGTT 10-20 compounds/week) with an in vivo technique
  • Initial in vivo insights into your compound’s efficacy on glucose homeostasis
  • Sensitivity (15%) to detect a statistically significant impact of your compound.

Description and parameters

The Glucose Tolerance Test investigates how diabetic animals treated with your compound regulate their glycemia after glucose.

Species

  • Rat
  • Mouse

Routes of administration

  • i.p., p.o.

Parameters evaluated

  • Glycemia profile

Glucose tolerance test in vivo proof of concept
Glucose tolerance test in vivo proof of concept

Add-on studies

REFERENCES

Cani PD. et al, Diabet, 2006 55: 1484-90.
Andreelli F. et al, Endocrinology, 2006,147: 2432-41.
Medina Gomez G. et al, Diabetes, 2005, 54: 1706-16.