The scientific focus adapted
to express the optimum potential
of your molecule

Marketing:
Unparalleled vision in metabolic disorders and risk assessment expertise for post-marketing studies and drug repositioning.

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Preclinical development:
In-house predictive models and tracer technologies enable the generation of Proof of Concept efficacy data for your drugs.

Discovery:
Screening and lead validation utilize a dedicated research platform which combine with our focused scientific vision.

Home > Nutraceuticals

Nutraceuticals

KEY BENEFITS

  • Outstanding scientific expertise and consultancy
  • Innovative in-house diet-induced animal models
  • Gold-standard methods and novel in-house techniques
  • Dedicated research platform to evaluate the proof of efficacy of your compounds in type 2 diabetes, obesity as well as other metabolic disorders and cardiovascular complications
  • Customized research solutions to target your needs

Our partner, Vaiomer

VaiomerBased on its pioneering research on the role of tissue microbiota in the initiation of the inflammatory cascade leading to metabolic disorders, Vaiomer’s vocation is to contribute to the discovery of innovative biomarkers, therapeutic targets and products for the early prognosis, prevention and treatment of cardiometabolic diseases.
Vaiomer has developed a unique platform to sequence, analyze and quantify gut, oral, blood and tissue microbiota to further validate nutritional and therapeutic strategies on microbiota dysbiosis-related diseases

Animal Experimental Models

Introduce to neutraceutical
Demonstrate benefits of your nutraceuticals and functional foods on deleterious health effects of Western Diet: metabolic syndrome and complications
Demonstrate benefits of your nutraceuticals and functional foods

Nutrional animal models

High fat diet mouse (78% fat)

In-house model: specific mouse model totally devoted to insulin resistance due to lipotoxicity.

A validated model for prebiotics  and probiotics  studies and low grade inflammation.

Prebiotics in HFD mouse model
Diet Induced Obesity (DIO) rat (40% fat)
A diet-induced obesity rat model that exhibit hyperglycemia, impaired insulin secretion, hepatic and peripheral resistance. A model to study pre-diabete type 2 diabetes and obesity.
Diet induced Obesity (DIO) rat model
High fat diet mouse (60% fat)
A reference mouse model dedicated to diabetes and obesity studies. (1) 
High fat diet mouse model 60%
Insulin Resistant and dyslipidemic hamster model
In-house model: a high fat fed hamster model with insulin resistance/diabetes, dyslipidemia and hepatic steatosis 
Insulin resistant and dyslipidemic hamster model
Insulin Resistant rat
First-in-class rat model fed a high fat, medium fructose, cholic acid diet combining visceral obesity, insulin resistance and NAFLD.
Insulin resistant rat

Genetic animal models

Ob/ob mouse
A leptin-deficient mouse model for type 2 diabetes, obesity.
Ob / ob mouse
Genetic animal models on request

Read-Outs

In vivo screening and profiling
Glucose homeostasis
Complementary techniques associated to diabetes and insulin resistance ico-linkYesYes
Lipid metabolism
Complementary techniques associated to lipid disorders ico-linkYesYes
Biochemistry / Biomarkers, Cardiometabolic parameters and basic services
Biochemistry / Biomarkersico-linkYesYes
Indirect calorimetryYesYes
Cardiometabolic parametersYesYes
Basic services Body weight, Food intake, Lipid homeostasis, Blood collection and tissue harvesting

 

Non invasive imaging services
Body compositionDual Energy X-Ray Absorptiometry (DEXA)