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Home > Insulin resistant hypertensive rat model

Insulin resistant hypertensive rat model

A model of insulin resistance associated with hypertension leading to early kidney dysfunction

key benefits

  • A proprietary diet induced model : take advantage of Physiogenex’s unique expertise with this model.
  • Assess the efficacy of your compound in a physiological and diet-induced model displaying major features of the onset of diabetic nephropathy in association with insulin resistance, hypertension.
  • Physiological model relevant to the main classes of approved anti-diabetic, anti-hypertensive compounds.

pharmacological validation

  • Positive reference compounds: exendin, metformin, ramipril

Fact sheet

Insulin resistant hypertensive rat model


Prunet- Maracssus B. et al. Prediabetes and Metabolic Syndrome Congress, 2011.