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Unparalleled vision in metabolic disorders and risk assessment expertise for post-marketing studies and drug repositioning.

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Preclinical development:
In-house predictive models and tracer technologies enable the generation of Proof of Concept efficacy data for your drugs.

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Screening and lead validation utilize a dedicated research platform which combine with our focused scientific vision.

Home > Insulin Resistant rat model

insulin resistant rat

First-in-class rat nutritional model combining obesity, insulin resistance and dyslipidemia

key benefits

  • Provides a noteworthy competitive advantage for your lead/drug compound, in terms of insulin resistance, obesity, dyslipidemia, and hepatic steatosis.
  • Merges glucose and lipid disorders in a UNIQUE animal model, for robust differentiation of your compound’s efficacy and unwanted effects.
  • Tailor-made nutritional model obtainable in 5 to 8 weeks, depending on your scientific needs.
  • Palatable diet leading to rapid weight gain to detect a statistically significant impact of your compound on body weight/food intake.

pharmacological validation

  • Positive reference compounds: rosiglitazone

Fact sheet

Insulin resistant rat

REFERENCES

Issandou M. et al. Eur J Pharmacol. 2009 Sep 15;618 (1-3): 28-36.