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Home > Diet Induced Obesity rat model

diet induced obesity (DIO) rat model

A nutritional rat model dedicated to obesity / insulin resistance studies

key benefits

  • To mimic gradual body weight gain, and especially visceral fat hypertrophy, as observed in western populations.
  • To select the best drug candidate in a very reproducible model, suitable for screening.
  • To test the efficacy of compounds in a model with sensitivity to all reference compounds tested close to clinical setting.

pharmacological validation

  • Positive reference compounds: sibutramin, pioglitazone, metformin

Fact sheet

Diet induced Obesity (DIO) rat model

REFERENCES

Roix JJ et al. Diabetes Obes Metab. 2012 Apr;14(4):329-34.
Prunet-Marcassus B. et al. Endocrinology. 2003 Dec: 144(12):5347-52.