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Home > Diet Induced Obesity mouse model

diet induced obesity (DIO) mouse model

A model to study pre-diabete type 2 diabetes and obesity

key benefits

  • To mimic gradual body weight gain, and especially visceral fat hypertrophy, as observed in western populations.
  • To select the best drug candidate in a very reproducible model, suitable for screening.
  • To test the efficacy of compounds in a model with sensitivity to all reference compounds tested close to clinical setting.

pharmacological validation

  • Positive reference compounds: metformin and pioglitazone

Fact sheet

DIO mouse 2018 thumbnail
DIO mouse 2018 thumbnail