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Unparalleled vision in metabolic disorders and risk assessment expertise for post-marketing studies and drug repositioning.

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Preclinical development:
In-house predictive models and tracer technologies enable the generation of Proof of Concept efficacy data for your drugs.

Discovery:
Screening and lead validation utilize a dedicated research platform which combine with our focused scientific vision.

Home > Hypercholesterolemic hamster

Hypercholesterolemic Hamster

A nutritional hamster model dedicated to cholesterol & lipoprotein metabolism studies

Key benefits

  • To select the best drug candidate in a very reproducible model with lipoprotein metabolism similar to humans (e.g.: high LDL-C levels and higher CETP activity)
  • To test the efficacy of novel drugs in a model validated with reference compounds

pharmacological validation

  • Positive reference compounds: fenofibrate, ezetimibe

Fact sheet

Hypercholesterolemic hamster

REFERENCES

Castro-Perez J. et al. J Lipid Res. 2011 Nov;52(11):1965-73.
ico-link
Treguier M. et al. Eur J Clin Invest. 2011 Sep;41(9):921-8.
Briand F. et al. J Lipid Res. 2010 Apr;51(4):763-70
Briand F. Curr Opin Investig Drugs. 2010 Mar;11(3):289-97.