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Unparalleled vision in metabolic disorders and risk assessment expertise for post-marketing studies and drug repositioning.

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In-house predictive models and tracer technologies enable the generation of Proof of Concept efficacy data for your drugs.

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Home > Adipocyte ex vivo lipolysis

Adipocyte ex vivo lipolysis

A simple and rapid method for assessing the effect on adipocyte lipolytic capacity of your compound designed to treat insulin resistance and/or obesity.
Suitable both for medium-scale screening purposes and for ex vivo proof of concept.

Key benefits

  • Ex vivo validation on lipolysis in isolated adipocytes for drugs directly targeting adipocytes
  • Ex vivo validation on the lipolytic capacity of adipocytes from animals treated chronically with a drug candidate
  • Insights into aspects of obesity and/or insulin resistance
  • Select your best candidates with a cheap, reproducible and rapid technique before launching in vivo validation

Parameters

Species

  • Rat
  • Mouse

Lipolytic capacity of adipocytes isolated from C57bl6/j or db/db mice. Lipolysis was stimulated by isoproterenol and inhibited by insulin
Lipolytic capacity of adipocytes isolated from C57bl6/j or db/db mice. Lipolysis was stimulated by isoproterenol and inhibited by insulin

Add-on studies