In vivo individual tissue glucose uptake
Unique solution for assessing the efficacy of your compound designed to treat type 2 diabetes on in vivo glucose uptake, tissue by tissue.
The individual tissue technique using radiotracers provides critical information on additional tissue-specific benefits as well as unwanted effects on key tissues, for rapid strategic decision-making.
Key benefits
- Information for stratifying future patient populations, with a whole body tissue-by-tissue overview of the effect of your compound
- Insights for devising ex vivo tissue assays for screening your hit compounds
- Identifying additional in vivo effects in specific tissues that would not have been seen in any other type of experiment.
- Anticipating adverse effects on major tissues: brain, heart, muscle, and adipose tissue.
Parameters evaluated
- Muscle glucose uptake: Extensor digitorium longus (EDL), Vastus lateralis (VL), Soleus (SOL),...
- White adipose tissue (WAT) glucose uptake: subcutaneous, visceral
- Organ glucose uptake: brain, heart and brown adipose tissues (BAT)
Add-on studies
- Free fatty acid turnover with specific emphasis on individual tissue FFA storage rates, yielding a whole body tissue-by-tissue overview of the effect of your compound on lipotoxicity.
Scientific publications
- Knauf C et al, J Clin Invest 115: 3554-63, 2005
- Cook S et al, Diabetes 53:2067-72, 2004
- Burcelin R et al, Diabetes 48: 16264-9, 1999
