State-of-the-art method for investigating your compound's efficacy on pancreatic ß-cell function in type 2 diabetes. Hyperglycemia is maintained to stimulate insulin secretion.
Key benefits
- Sensitivity to detect a statistically significant impact of your compound on insulin secretion,
- Designed to gain an overview of pancreatic β-cell function in vivo
- Essential and robust data for your records: a unique tool simultaneously integrating all factors involved in the control of insulin secretion (metabolites, hormones, neuroregulatory factors).
Species
- Rat
- Mouse
Add-on studies
- GLP-1 active form in the portal vein after an oral glucose load, to investigate the efficacy of your compound on GLP-1 production.
Scientific publications
- Knauf C et al, J Clin Invest 115: 3554-63, 2005
- Burcelin R et al, Diabetes 50 : 1282-9, 2001
- Thorens B et al, J. Biol.Chem 275: 23751-8, 2000
