Parameters evaluated
- FFA fluxes
- FFA turnover
- Whole-body oxidation rate
- Whole-body storage rate
- Plasma FFA appearance
- FFA clearance rate
A pioneering technique for quantifying the direct effect of your compound on LIPOTOXICITY related to type 2 diabetes and obesity.
Free fatty acid turnover using RADIOLABELED TRACERS is invaluable for assessing whole body lipid trafficking and circulation in vivo.
Key Benefits
- In vivo validation on impaired free fatty acid metabolism
- Sensitivity (15%) sufficient to detect a statistically significant impact of your compound on lipid trafficking: a lack of significant results for plasma FFA does not imply your drug compound doesn't improve FFA turnover
- Predictive of individual tissue lipotoxicity
Species
- Rat
- Mouse
Add-on studies
- Individual tissue FFA storage rate: a whole-body tissue-by-tissue overview of the effect of your compound on lipotoxicity.
- Hepatic VLDL-TG production.
- Whole body glucose turnover: complete the overview of your drug compound's impact on glucose metabolism.
