Insulin tolerance test

Liver

Adipose tissue

Muscle

First in vivo proof-of-concept method for your compound's impact on INSULIN SENSITIVITY.
The Insulin tolerance test shows how diabetic animals regulate their glycemia after insulin stimulation.

Key benefits

Capacity to screen compounds in vivo on a large scale (20-30 compounds/week), with a cheap and reproducible in vivo technique
Sensitivity (15%) to detect a statistically significant impact of your compound on insulin sensitivity

Species

Rat
Mouse

Parameters evaluated

Plasma glucose

Add-on studies

Hyperinsulinemic euglycemic clamp + 3H glucose to further investigate the effect of your compound on insulin sensitivity in a “gold standard" test for preclinical validation or lead selection.
Glucose tolerance test and lipid tolerance test on the same animals to reinforce your validation on complementary issues

Scientific publications

Bardoux P et al, Diabetes 54: 1357-63, 2005
Medina Gomez G et al, Diabetes 54: 1706-16, 2005

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