A simple and rapid method for assessing the effect on adipocyte lipolytic capacity of your compound designed to treat insulin resistance and/or obesity.
Suitable both for medium-scale screening purposes and for ex vivo proof of concept.
Key benefits
- Ex vivo validation on lipolysis in isolated adipocytes for drugs directly targeting adipocytes
- Ex vivo validation on the lipolytic capacity of adipocytes from animals treated chronically with a drug candidate
- Insights into aspects of obesity and/or insulin resistance
- Select your best candidates with a cheap, reproducible and rapid technique before launching in vivo validation
Species
- Rat
- Mouse
Add-on studies
- Basal glucose turnover test.and/or euglycemic hyperinsulinemic clamp + 3H-glucose for in vivo validation
