A simple and rapid technique for assessing your compound's direct effect on glucose uptake in type 2 diabetes and/or obesity.
This method can be used both for medium throughput screening and for initial ex vivo proof-of-concept.
Key benefits
- Ex vivo validation on glucose uptake in isolated muscles (a major contributor to blood glucose control)
- Ex vivo validation on glucose uptake in isolated adipocytes for drugs targeting these cells
- Insights into obesity and/or insulin resistance
- Select your best candidates with an inexpensive, reproducible and rapid technique before launching in vivo validation
Species
- Rat
- Mouse
Add-on studies
- Basal glucose turnover.and/or euglycemic hyperinsulinemic clamp + 3H-glucose for in vivo validation
Scientific publications
- Viollet B et al, J. Clin Invest 111: 3554-63, 2003
- Duplain H et al, Circulation 104: 342-5, 2001
