Pathophysiological features and scientific data
A tailor-made nutritional animal model that enables the study of the non-alcoholic fatty liver disease (NAFLD) progression to better predict the therapeutic potency of drugs
The NASH Rat model’s key features:
- Test drugs along the NAFLD ranging from fatty liver, lobular inflammation, fibrosis and cirrhosis.
- Test drugs in insulin resistance/obesity context known as a major risk factor for NASH.
- A model reflecting the pathophysiology of NASH in humans using a high-fat diet approach.
Animal Models:
- Background Strain: Sprague-Dawley rat
- Gender/Weight: Male 250-275g
- High Fat Medium Fructose Diet (HF-MFD): High fat (65%) + cholesterol + cholic acid + 15% fructose
- Time on diet: from 2 weeks for studying fatty liver to 3 months for having necrosis and cirrhosis
- Positive reference compounds: contact us
Macroscopical examination of fatty liver
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Histological evidence of steatohepatitis
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Microscopical examination: Histological analysis (hemalum-eosin, periodic acid schiff and Masson trichrome)
