Publications

Dyslipidemia

Briand F, Thieblemont Q, Burcelin R, Sulpice T.
Sitagliptin promotes macrophage-to-feces reverse cholesterol transport through reduced intestinal cholesterol absorption in obese insulin resistant CETP-apoB100 transgenic mice.
Diabetes Obes Metab. 2012 Jan 23. [Epub ahead of print]

Briand F, Thieblemont Q, André A, Ouguerram K, Sulpice T.
CETP inhibitor Torcetrapib promotes reverse cholesterol transport in obese insulin-resistant CETP-ApoB100 transgenic mice.

Clin Transl Sci. 2011 Dec;4(6): 414-420.

Castro-Perez J, Briand F, Gagen K, Wang SP, Chen Y, McLaren DG, Shah V, Vreeken RJ, Hankemeier T, Sulpice T, Roddy TP, Hubbard BK, Johns DG.

Anacetrapib promotes reverse cholesterol transport and bulk cholesterol excretion in Syrian golden hamsters.

J Lipid Res. 2011 Nov;52(11):1965-73.

Nijstad N, Gautier T, Briand F, Rader DJ, Tietge UJ.

Biliary sterol secretion is required for functional in vivo reverse cholesterol transport in mice.

Gastroenterology. 2011 Mar;140(3):1043-51.

Tréguier M, Briand F, Boubacar A, André A, Magot T, Nguyen P, Krempf M, Sulpice T, Ouguerram K.

Diet-induced dyslipidemia impairs reverse cholesterol transport in hamsters.

Eur J Clin Invest. 2011 Sep;41(9):921-8.

Li X, Millar JS, Brownell N, Briand F, Rader DJ.

Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes.

Biochem Pharmacol. 2010 Nov 1;80(9):1450-7.

Fabre AC, Malaval C, Ben Addi A, Verdier C, Pons V, Serhan N, Lichtenstein L, Combes G, Huby T, Briand F, Collet X, Nijstad N, Tietge UJ, Robaye B, Perret B, Boeynaems JM, Martinez LO.

P2Y13 receptor is critical for reverse cholesterol transport.
Hepatology. 2010 Oct;52(4):1477-83.

Briand F, Tréguier M, André A, Grillot D, Issandou M, Ouguerram K, Sulpice T.

Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model.

J Lipid Res. 2010 Apr;51(4):763-70

Briand F.

The use of dyslipidemic hamsters to evaluate drug-induced alterations in reverse cholesterol transport.

Curr Opin Investig Drugs. 2010 Mar;11(3):289-97.

Briand F, Naik SU, Fuki I, Millar JS, Macphee C, Walker M, Billheimer J, Rothblat G, Rader DJ.

Both the Peroxisome Proliferator-Activated Receptor Agonist, GW0742, and Ezetimibe Promote Reverse Cholesterol Transport in Mice by Reducing Intestinal Reabsorption of HDL-Derived Cholesterol.

Clin trans Sci. 2009; 2:127-133.

Briand F, Bailhache E, Andre A, Magot T, Krempf M, Nguyen P, Ouguerram K.

The hyperenergetic-fed obese dog, a model of disturbance of apolipoprotein B-100 metabolism associated with insulin resistance: kinetic study using stable isotopes.

Metabolism. 2008 Jul;57(7):966-72.

Briand F, Bailhache E, Nguyen P, Krempf M, Magot T, Ouguerram K.

Metabolism of high density lipoprotein apolipoprotein A-I and cholesteryl ester in insulin resistant dog: a stable isotope study.

Diabetes Obes Metab. 2007 Jan;9(1):139-42.

Serisier S, Briand F, Ouguerram K, Siliart B, Magot T, Nguyen P.

Fenofibrate lowers lipid parameters in obese dogs.

Nutr. 2006 Jul;136(7 Suppl):2037S-2040S.

Briand F, Serisier S, Krempf M, Siliart B, Magot T, Ouguerram K, Nguyen P.

Atorvastatin increases intestinal cholesterol absorption in dogs.

J Nutr. 2006 Jul;136(7 Suppl):2034S-2036S.

Briand F, Magot T, Krempf M, Nguyen P, Ouguerram K.

Effects of atorvastatin on high-density lipoprotein apolipoprotein A-I metabolism in dogs.

Eur J Clin Invest. 2006 Apr;36(4):224-30.

Ouguerram K, Nguyen P, Krempf M, Pouteau E, Briand F, Bailhache E, Magot T.

Selective uptake of high density lipoproteins cholesteryl ester in the dog, a species lacking in cholesteryl ester transfer protein activity; An in vivo approach using stable isotopes.

Comp Biochem Physiol B Biochem Mol Biol. 2004 Aug;138(4):339-45.

Bailhache E, Briand F, Nguyen P, Krempf M, Magot T, Ouguerram K.

Metabolism of cholesterol ester of apolipoprotein B100-containing lipoproteins in dogs: evidence for disregarding cholesterol ester transfer.

Eur J Clin Invest. 2004 Aug;34(8):527-34.

Posters

American Heart Association 2011 - Poster

Briand F, Thieblemont Q, Muzotte E, Sulpice T.
Reduction of apolipoprotein E-rich HDL levels with Berberine stimulates reverse cholesterol transport in hyperlipidemic hamsters treated with CETP inhibitor Torcetrapib.
American Heart Association, November 12-16, 2011, Orlando, Florida, USA.

Poster American Diabetes Association 71st Scientific Sessions June 24th-28th, 2011. San Diego, CA, USA

Briand F, Burcelin R, Sulpice T.
DPP-4 Inhibitor sitagliptin improves reverse cholesterol transport through reduced intestinal cholesterol absorption in obese insulin resistant CETP-apoB100 transgenic mice.
American Diabetes Association , June 24-28, 2011, San Diego, California, USA.

Diabetes & Obesity

Publications

Roix JJ, Decrescenzo GA, Cheung PH, Ciallella JR, Sulpice T, Saha S, Halse R.
Effect of the antipsychotic agent amisulpride on glucose lowering and insulin secretion.
Diabetes Obes Metab. 2011 Nov 7. [Epub ahead of print]

Amar J, Chabo C, Waget A, Klopp P, Vachoux C, Bermúdez-Humarán LG, Smirnova N, Bergé M, Sulpice T, Lahtinen S, Ouwehand A, Langella P, Rautonen N, Sansonetti PJ, Burcelin R.

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment.
EMBO Mol Med. 2011 Sep;3(9):559-72.

Waget A, Cabou C, Masseboeuf M, Cattan P, Armanet M, Karaca M, Castel J, Garret C, Payros G, Maida A, Sulpice T, Holst JJ, Drucker DJ, Magnan C, Burcelin R.

Physiological and pharmacological mechanisms through which the DPP-4 inhibitor Sitagliptin regulates glycemia in mice.

Endocrinology. 2011 Aug 15;2(8):3018-29.

Chabo C, Amar J, Waget A, Klopp P, Vachoux C, Smirnova N, Bergé M, Sulpice T, Lahtinen S, Ouwehand A, Rautonen N, Sansonetti P, Burcelin R.
La translocation de bactéries intestinales vers les tissus adipeux initie l’inflammation et le diabète induits par un régime gras chez la souris.
Diabetes & Metabolism. 2011 Mar;37(1, S1):A7

Issandou M, Bouillot A, Brusq JM, Forest MC, Grillot D, Guillard R, Martin S, Michiels C, Sulpice T, Daugan A.

Pharmacological inhibition of Stearoyl-CoA Desaturase 1 improves insulin sensitivity in insulin-resistant rat models.

Eur J Pharmacol. 2009 Sep 15;618(1-3):28-36

Sulpice T, Prunet-Marcassus B, Molveaux C, Cani P, Vitte PA, Graber P, Dreano M, Burcelin R.

An adiponectin-like molecule with antidiabetic properties.

Endocrinology. 2009 Oct;150(10):4493-501

Poglio S, Galvani S, Bour S, André M, Prunet-Marcassus B, Pénicaud L, Casteilla L, Cousin B.

Adipose tissue sensitivity to radiation exposure.

Am J Pathol. 2009 Jan;174(1):44-53.

Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmée E, Cousin B, Sulpice T, Chamontin B, Ferrières J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R.

Metabolic endotoxemia initiates obesity and insulin resistance.

Diabetes. 2007 Jul;56(7):1761-72.

Fyfe MC, White JR, Taylor A, Chatfield R, Wargent E, Printz RL, Sulpice T, McCormack JG, Procter MJ, Reynet C, Widdowson PS, Wong-Kai-In P.

Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions.

Diabetologia. 2007 Jun;50(6):1277-87.

Prunet-Marcassus B, Cousin B, Caton D, André M, Pénicaud L, Casteilla L.

From heterogeneity to plasticity in adipose tissues: site-specific differences.

Exp Cell Res. 2006 Apr 1;312(6):727-36.

Carmona MC, Louche K, Nibbelink M, Prunet B, Bross A, Desbazeille M, Dacquet C, Renard P, Casteilla L, Pénicaud L.

Fenofibrate prevents Rosiglitazone-induced body weight gain in ob/ob mice.

Int J Obes, 2005 Jul;29(7):864-71.

Prunet-Marcassus B, Desbazeille M, Bros A, Louche K, Delagrange P, Renard P, Casteilla L, Pénicaud L.

Melatonin reduces body weight gain in Sprague Dawley rats with diet-induced obesity.

Endocrinology. 2003 Dec;144(12):5347-52.

Prunet-Marcassus B, Ambid L, Viguerie-Bascands N, Pénicaud L, Casteilla L.

Evidence for a direct effect of melatonin on mitochondrial genome expression of Siberian hamster brown adipocytes.

J Pineal Res. 2001 Mar;30(2):108-15.

Prunet-Marcassus B, Moulin K, Carmona MC, Villarroya F, Pénicaud L, Casteilla L.

Inverse distribution of uncoupling proteins expression and oxidative capacity in mature adipocytes and stromal-vascular fractions of rat white and brown adipose tissues.

FEBS Lett. 1999 Dec 31;464(3):184-8.

Posters

Prediabetes & Metabolic Syndrome Poster Presentation 2011

Prunet-Marcassus B, Jaafar F, Muzotte E, Al Saati T, Tack T, Sulpice T.
Antidiabetic drugs exendin-4 and metformin prevent renal damages independently of blood glucose reduction in insulin resistant hypersensitive Dahl rats fed a high salt/sucrose diet.
Prediabetes and Metabolic Syndrome Congress, April 6th-9th,2011. Madrid, Spain.

Cardiovascular diseases

Grauzam S, Toufektsian MC, Ormezzano O, Jouan MG, Boucher F, Sulpice T.
Dietary-induced insulin resistance associated with dyslipidemia induces progressive cardiac dysfunction in rats as evidenced by echocardiocardiography.
Arch Cardiovasc Dis. 2009 Mar;102(S1):22.

Berthonneche C, Sulpice T, Tanguy S, O'Connor S, Herbert JM, Janiak P, de Leiris J, Boucher F.

AT1 receptor blockade prevents cardiac dysfunction after myocardial infarction in rats.

Cardiovasc Drugs Ther. 2005 Aug;19(4):251-9.

Berthonneche C, Sulpice T, Boucher F, Gouraud L, de Leiris J, O'Connor SE, Herbert JM, Janiak P.

New insights into the pathological role of TNF-alpha in early cardiac dysfunction and subsequent heart failure after infarction in rats.

Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H340-50.

Leducq N, Bono F, Sulpice T, Vin V, Janiak P, Fur GL, O'Connor SE, Herbert JM.

Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion.

J Pharmacol Exp Ther. 2003 Sep;306(3):828-37.

Pucheu S, Boucher F, Sulpice T, Tresallet N, Bonhomme Y, Malfroy B, de Leiris J.

EUK-8 a synthetic catalytic scavenger of reactive oxygen species protects isolated iron-overloaded rat heart from functional and structural damage induced by ischemia/reperfusion.

Cardiovasc Drugs Ther. 1996 Jul;10(3):331-9.

Sulpice T, Boucher F, de Leiris J.

Limiting lipid peroxidation in the nonischemic zone of infarcted rat hearts by indomethacin improves left ventricular function without affecting myocardial healing and remodeling.

Am Heart J. 1996 Apr;131(4):681-8.

Sulpice T, Boucher F, Pucheu S, de Leiris J.

Contribution of leukocyte infiltration to lipoperoxidation occurring in the non-ischemic region of the rat heart submitted to permanent left coronary artery occlusion.

J Mol Cell Cardiol. 1994 Jul;26(7):831-40.

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